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Three-year extension study of lanthanum carbonate therapy in Japanese hemodialysis patients

Takashi Shigematsu1,

  • 1Division of Nephrology and Blood Purification Medicine, Department of Medicine, Wakayama Medical University, 881-1 Kimiidera, Wakayama, Wakayama 641-8509, Japan. taki@wakayama-med.ac.jp

Clinical and Experimental Nephrology
|September 4, 2010
PubMed

Insights

Lanthanum carbonate effectively lowered serum phosphate in Japanese dialysis patients for three years. The treatment demonstrated a favorable safety profile with mostly mild gastrointestinal events, maintaining phosphate levels within guidelines.

Area of Science:

  • Nephrology
  • Pharmacology
  • Biochemistry

Background:

  • Lanthanum carbonate is a phosphate binder for dialysis patients.
  • Previous studies reported its efficacy and safety up to one year in Japanese hemodialysis patients.

Purpose of the Study:

  • To evaluate the long-term efficacy and safety of lanthanum carbonate.
  • To assess serum phosphate reduction and bone turnover markers over three years.

Main Methods:

  • An extension study of 63 patients from a 1-year Phase III trial.
  • Lanthanum carbonate administered at 750-4,500 mg/day for up to 156 weeks.
  • Efficacy assessed by serum phosphate reduction; safety monitored via adverse events and laboratory markers.

Main Results:

  • Serum phosphate levels were significantly reduced and maintained below baseline throughout the 3-year study (P < 0.05).
  • The safety profile was consistent with previous findings, with mild gastrointestinal disorders being the most common adverse events.
  • No clinically significant changes were observed in vital signs, ECG, or bone turnover markers.

Conclusions:

  • Lanthanum therapy effectively reduced and maintained serum phosphate levels within recommended guidelines for Japanese dialysis patients over three years.
  • The long-term safety profile of lanthanum carbonate is favorable.
Abstract

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