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Updated: Jun 9, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
A diversity-oriented synthesis of pyrazolo[4,3-f]quinoline derivatives with potential bioactivities via
Feng Shi1, Shu Zhang, Shan-Shan Wu
1School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, Jiangsu, 221116, People's Republic of China.
Abstract:
Six new series of pyrazolo[4,3-f]quinoline derivatives with potential bioactivities were synthesized by the three-component reactions of aromatic aldehydes, 5-aminoindazole, and various cyclic 1,3-dicarbonyl compounds under microwave irradiation. This protocol has the valuable features of structural diversity of products, broader substrate scope, operational simplicity, high yields, and short reaction time. Moreover, the structure of compound 88a was confirmed by an X-ray crystallographic analysis and attested to the chemoselectivity of reaction where 1-methyl barbituric acid participated.
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