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Disorders of Erythrocytes01:27

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
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Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
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Published on: January 31, 2022

Iron deficiency: beyond anemia.

Dinesh Yadav1, Jagdish Chandra

  • 1Department of Pediatrics, Kalawati Saran Children's Hospital and Lady Hardinge Medical College, New Delhi, India. dineshmamc@gmail.com

Indian Journal of Pediatrics
|September 4, 2010
PubMed
Summary
This summary is machine-generated.

Iron deficiency, a widespread nutritional issue, impacts more than just anemia. It can cause irreversible brain development problems and is linked to various other health concerns, including infections.

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Published on: May 4, 2020

Area of Science:

  • Nutrition Science
  • Pediatric Health
  • Immunology

Background:

  • Iron deficiency is the most prevalent nutritional disorder globally, affecting over a third of the population.
  • While anemia is a known consequence, other systemic effects of iron deficiency are often overlooked.
  • Cognitive, behavioral, and psychomotor impairments, particularly in young children, are significant concerns.

Purpose of the Study:

  • To review the under-recognized effects of iron deficiency beyond anemia.
  • To highlight the impact of iron deficiency on brain development and its potential irreversibility.
  • To discuss the controversial relationship between iron deficiency, immunity, and infection susceptibility.

Main Methods:

  • Literature review of studies on iron deficiency.
  • Analysis of research on neurological and developmental impacts.
  • Examination of immunological findings and infection associations.

Main Results:

  • Iron deficiency can lead to irreversible brain development issues in children under two.
  • Associations with conditions like febrile seizures, pica, and restless leg syndrome are increasingly recognized.
  • The link between iron deficiency and infection susceptibility is complex and debated, with some studies showing increased malaria incidence with iron supplementation.

Conclusions:

  • Iron deficiency has wide-ranging, often under-recognized, health implications beyond anemia.
  • Early-life iron deficiency poses risks for irreversible neurodevelopmental deficits.
  • The impact of iron status on immunity and infection requires further investigation, especially in vulnerable populations.