Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Profile of a large-scale cohort study.

A P Fletcher1

  • 1IMS International, London, United Kingdom.

Drugs
|January 1, 1990
PubMed
Summary

This observational study monitored 10,800 patients on nabumetone and 2005 on other nonsteroidal anti-inflammatory drugs (NSAIDs). The methodology effectively gathered real-world data on patient demographics, diagnoses, drug use, and clinical events.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An investigation into the suitability of a commercial real-time PCR assay to screen for Taylorella equigenitalis in routine prebreeding equine genital swabs.

Equine veterinary journal·2010
Same author

The safety of medicinal products--current attitudes--better or just new?

Adverse drug reactions and toxicological reviews·2002
Same author

MMR safety studies.

Adverse drug reactions and toxicological reviews·2001
Same author

EU pharmacovigilance guidelines. Review.

Adverse drug reactions and toxicological reviews·2000
Same author

Source Informatics Ltd versus Department of Health: appeal court reverses judgement of Mr Justice Latham and allows use of anonymized patient information without consent.

Adverse drug reactions and toxicological reviews·2000
Same author

Aggression as an adverse drug reaction.

Adverse drug reactions and toxicological reviews·2000

Area of Science:

  • Pharmacovigilance
  • Real-world evidence in rheumatology
  • General practice research

Background:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for pain and inflammation.
  • Nabumetone is a commonly used NSAID.
  • Understanding NSAID use and outcomes in general practice is crucial for patient safety and effective treatment.

Purpose of the Study:

  • To monitor clinical events and adverse reactions in patients treated with nabumetone compared to other NSAIDs.
  • To evaluate the feasibility of collecting real-world data on NSAID use in UK general practice.
  • To assess demographic, diagnostic, and drug usage patterns in a large cohort.

Main Methods:

  • An event-monitoring, observational cohort study design.
  • Involved 10,800 patients treated with nabumetone and 2005 patients on other NSAIDs.
  • Data collected by 2986 UK general practitioners over 12 months via registration and follow-up reports.

Main Results:

  • The study successfully collected comprehensive data on demographics, diagnoses, drug use, clinical events, and adverse reactions.
  • The developed methodology proved effective for real-world data acquisition in everyday medical practice.
  • Detailed insights into NSAID utilization and patient outcomes were obtained.

Conclusions:

  • The study demonstrated a successful methodology for collecting real-world data on NSAID use in general practice.
  • The data gathered provides valuable insights into the safety and effectiveness of nabumetone and other NSAIDs in routine clinical settings.
  • This approach supports ongoing pharmacovigilance and evidence-based prescribing of NSAIDs.

Related Experiment Videos