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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
[A diterpenoid quinone from Periploca forrestii]
Yan Wang1, Lei Sun, Shanyi Qiao
1Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China.
Summary
Tanshinone II A, a compound unique to Salvia, was isolated from Periploca forrestii. This anti-inflammatory diterpenoid quinone marks its first discovery in this plant genus.
Area of Science:
- Phytochemistry
- Natural Product Chemistry
Context:
- Periploca forrestii is a plant source of bioactive compounds.
- Tanshinone II A is a known diterpenoid quinone with anti-inflammatory properties, typically found in Salvia species.
Purpose:
- To isolate and identify compounds from the ethanol extract of Periploca forrestii.
- To investigate the presence of Tanshinone II A in Periploca forrestii.
Summary:
- Tanshinone II A was successfully separated and purified using silica gel column chromatography and recrystallisation.
- The compound was obtained from the ethyl acetate-soluble portion of the ethanol extract, identified as the anti-inflammatory active fraction.
- This marks the first reported isolation of Tanshinone II A from the Periploca genus.
Impact:
- Establishes Periploca forrestii as a novel source of Tanshinone II A.
- Provides a new avenue for the study and potential application of this anti-inflammatory compound.
- Contributes to the understanding of diterpenoid quinone distribution in medicinal plants.
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