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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Corrigendum: Monte Carlo simulated corrections for beam commissioning measurements with circular and MLC shaped fields on the CyberKnife M6 system: a study including diode, microchamber, point scintillator, and synthetic microdiamond detectors (2017<i>Phys. Med. Biol</i>.<b>62</b>1076).

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Updated: Jun 9, 2026

Stereotactic Radiosurgery for Gynecologic Cancer

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

The CyberKnife Robotic Radiosurgery System in 2010.

W Kilby¹, J R Dooley, G Kuduvalli

¹Accuray Incorporated, 1310 Chesapeake Terrace, Sunnyvale, CA 94089, USA. wkilby@accuray.com

Technology in Cancer Research & Treatment

|September 7, 2010

Summary

This summary is machine-generated.

The CyberKnife VSI System, released in 2009, significantly enhances treatment accuracy and quality through technical advancements. This updated review details its subsystems and improved geometric and dosimetric performance.

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Area of Science:

Medical Physics
Radiotherapy Technology

Background:

The CyberKnife VSI System represents a significant upgrade to the original CyberKnife platform, released in September 2009.
Previous technical reviews of the CyberKnife system were published in the late 1990s, necessitating an update on recent advancements.

Purpose of the Study:

To provide a comprehensive technical description of the CyberKnife VSI System.
To review the technical developments impacting the system over the past decade.
To assess the geometric accuracy and discuss the expanded clinical applications enabled by these advancements.

Main Methods:

Detailed system overview of key subsystems.
Review of geometric accuracy studies, including phantom tests and patient data.
Analysis of technical developments in inverse treatment planning, dose calculation, and post-processing tools.

Main Results:

Technical developments have improved geometric accuracy and enhanced dosimetric accuracy and treatment quality.
Advanced algorithms (e.g., Monte Carlo dose calculation) and post-processing tools offer trade-offs between efficiency and quality.
Geometric accuracy studies report a wide range of experimental findings.

Conclusions:

The CyberKnife VSI System incorporates substantial technical improvements over its predecessor.
These advancements have led to increased geometric and dosimetric accuracy, enhancing treatment efficacy.
The technical evolution of the CyberKnife system has broadened its clinical applicability.