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Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Drug Accumulation During Multiple Dosing: Repetitive IV Injections01:21

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

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Related Experiment Video

Updated: Jun 9, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
06:39

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

Gestational weight gain in consecutive pregnancies.

Jeanette R Chin1, Katrina M Krause, Truls Ostbye

  • 1Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, UT, USA. jeanette.chin@hsc.utah.edu

American Journal of Obstetrics and Gynecology
|September 7, 2010
PubMed
Summary
This summary is machine-generated.

A woman's gestational weight gain (GWG) pattern in her first pregnancy strongly predicts her GWG in the second pregnancy. This finding highlights the importance of monitoring GWG for maternal health.

Related Experiment Videos

Last Updated: Jun 9, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
06:39

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

Area of Science:

  • Reproductive Health
  • Maternal-Fetal Medicine
  • Public Health Nutrition

Background:

  • Gestational weight gain (GWG) is a critical factor influencing maternal and infant health outcomes.
  • Understanding the recurrence of GWG patterns across pregnancies can inform targeted interventions.

Purpose of the Study:

  • To investigate the association between gestational weight gain (GWG) categories in a woman's first and second pregnancies.
  • To determine if GWG in the first pregnancy predicts GWG in the second pregnancy.

Main Methods:

  • Retrospective observational cohort study utilizing data from North Carolina's Pregnancy Nutrition Surveillance System (1996-2004).
  • Included 27,771 women with both first and second births.
  • GWG categorized as inadequate, appropriate, or excessive based on 2009 Institute of Medicine guidelines.
  • Covariate-adjusted polytomous logistic regression analysis performed.

Main Results:

  • Women with excessive GWG in their first pregnancy had a 2.6 times higher odds of excessive GWG in their second pregnancy (95% CI, 2.4-2.7).
  • Women with inadequate GWG in their first pregnancy showed a similar likelihood of repeating inadequate GWG in their subsequent pregnancy.
  • First pregnancy GWG category is a significant predictor of second pregnancy GWG category.

Conclusions:

  • Gestational weight gain patterns are consistent across consecutive pregnancies.
  • First pregnancy GWG serves as a significant predictor for subsequent pregnancy GWG.
  • Findings emphasize the need for continuous monitoring and management of GWG.