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Cancer-Critical Genes II: Tumor Suppressor Genes

Cancer-Critical Genes II: Tumor Suppressor Genes

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Cancer-Critical Genes II: Tumor Suppressor Genes

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Updated: Jun 9, 2026

Glycan Node Analysis: A Bottom-up Approach to Glycomics

Glycan Node Analysis: A Bottom-up Approach to Glycomics

Published on: May 22, 2016

Core3 glycan as tumor suppressor.

Seung Ho Lee¹, Minoru Fukuda

¹Tumor Microenvironment Program, Cancer Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California, USA.

Methods in Enzymology

|September 7, 2010

Summary

Core3 O-glycan, synthesized by core3 synthase, suppresses prostate cancer progression. Ectopic expression of core3 synthase reduced tumor formation and metastasis by regulating integrin alpha2beta1 functions, indicating a tumor suppressor role.

Area of Science:

Glycobiology
Cancer Biology
Molecular Oncology

Background:

Mucin-type O-glycans play roles in tumorigenesis.
Increased core2 O-glycan is linked to cancer progression.
The function of core3 O-glycan in tumorigenesis is largely unknown.

Purpose of the Study:

To investigate the function of core3 O-glycan in cancer.
To understand the role of core3 synthase in tumor formation and metastasis.

Main Methods:

Ectopic expression of core3 synthase in prostate cancer cells.
Tumor formation assays.
Analysis of integrin alpha2beta1 maturation and heterodimerization.

Main Results:

Prostate cancer cells expressing core3 synthase showed decreased tumor formation.

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Glycan Node Analysis: A Bottom-up Approach to Glycomics

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Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

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Metastasis to lymph nodes was reduced in core3-expressing cells.

Core3 O-glycan attenuated integrin alpha2beta1 maturation and heterodimerization.

Conclusions:

Core3 O-glycan acts as a tumor suppressor in prostate cancer.
The tumor-suppressive function of core3 O-glycan is mediated by regulating integrin alpha2beta1 functions.