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The Ashwell-Morell receptor.

Prabhjit K Grewal1

  • 1The Department of Molecular, Cellular, and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, USA.

Methods in Enzymology
|September 7, 2010
PubMed
Summary
This summary is machine-generated.

The Ashwell-Morell receptor (AMR) clears desialylated prothrombotic molecules, such as platelets, to prevent lethal coagulopathy in sepsis. This liver receptor plays a vital role in hemostasis and survival.

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Area of Science:

  • Biochemistry
  • Immunology
  • Hematology

Background:

  • The Ashwell-Morell receptor (AMR), a mammalian C-type lectin, recognizes and clears asialoglycoproteins.
  • Endogenous AMR ligands include desialylated prothrombotic components like platelets and von Willebrand Factor.
  • Liver AMR-mediated clearance is crucial for mitigating sepsis-induced coagulopathy.

Purpose of the Study:

  • To overview endogenous ligands of the AMR within the coagulatory system.
  • To describe liver clearance mechanisms involving the AMR.
  • To detail hematology and coagulation assays used in mouse models.

Main Methods:

  • Identification of endogenous AMR ligands.
  • Investigation of AMR's role in sepsis-induced coagulopathy.
  • Utilization of mouse coagulation studies with hematology assays.

Main Results:

  • AMR binds desialylated prothrombotic components, including platelets and von Willebrand Factor.
  • Exposure of terminal galactose enhances AMR-mediated clearance.
  • AMR engagement mitigates disseminated intravascular coagulopathy in sepsis, promoting survival.

Conclusions:

  • The AMR is a key regulator of hemostasis by clearing prothrombotic factors.
  • AMR-mediated clearance is a critical survival mechanism during sepsis.
  • Understanding AMR function and assays is vital for coagulation research.