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Updated: Jun 9, 2026

In-Nucleus Hi-C in Drosophila Cells
Published on: September 15, 2021
Dynamic organization of chromatin assembly and transcription factories in living cells
Bidisha Sinha1, Dipanjan Bhattacharya, Deepak Kumar Sinha
1National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bellary Road, Bangalore 560065, India.
Abstract:
The interphase nucleus is an active organelle involved in processing genetic information. In higher order eukaryotes, information control is compartmentalized - for example at the scale of inter-chromosome territories and nuclear bodies. Regulatory proteins, nuclear bodies and chromatin assembly are found to be highly dynamic within the nucleus of primary cells and through cellular differentiation programs. In this chapter we describe live-cell fluorescence based techniques and single particle tracking analysis, to probe the spatio-temporal dimension in nuclear function.
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