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An analysis of the interactions between individual comorbidities and their treatments--implications for guidelines
Stephen P Fitzgerald1, Nigel G Bean
1Internal Medicine, Royal Adelaide Hospital, Australia. Stephen.Fitzgerald@health.sa.gov.au
Background:
With aging there is an increase in frailty and chronic disease leading to a potential increase in medication use. Most clinical trials have excluded old, frail individuals and have failed to take into account the effects of outcome interaction.
Methods And Results:
In this article we provide a mathematical model demonstrating that comorbidities, including old age, interact with therapies, reducing their effectiveness.
Conclusion:
These findings question the validity of single disease guidelines in old persons or in persons with multiple chronic diseases.
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