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Related Experiment Video

Updated: Jun 9, 2026

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

Biological sciences related to headache.

Toshihiko Shimizu¹, Norihiro Suzuki

¹Department of Neurology, School of Medicine, Keio University, Tokyo, Japan. shimizu-toshi@umin.ac.jp

Handbook of Clinical Neurology

|September 7, 2010

Summary

Headache arises from activated pain-sensitive cranial structures. Primary afferent neurons, including C and Adelta fibers, transmit pain signals to the brainstem via the trigeminal and upper cervical spinal nerves.

Area of Science:

Neuroscience
Anatomy

Background:

Headache involves pain-sensitive cranial structures like the dura mater, vasculature, and cranial/cervical muscles.
Primary afferent neurons, originating from trigeminal and upper cervical dorsal root ganglia, innervate these structures.

Purpose of the Study:

To discuss the anatomy relevant to headache perception.
To explore the role of specific nerve fibers and pathways in transmitting headache pain.

Main Methods:

Review of nerve stimulation studies.
Discussion of anatomical structures involved in nociception.

Main Results:

C fibers transmit slow-building, aching pain; Adelta fibers conduct sharp, initial pain.
Nociceptive information travels through trigeminal and upper cervical ganglia to the brainstem's spinal trigeminal nucleus.

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Last Updated: Jun 9, 2026

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Conclusions:

Understanding the anatomy of cranial structures and their innervation is crucial for headache research.
The trigeminal and upper cervical pathways are key in transmitting headache-related pain signals.