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Updated: Jun 9, 2026

Exploring Protein-Glycan Interactions: Advances in Nuclear Magnetic Resonance
Published on: August 26, 2025
Dynamics and interactions of glycoconjugates probed by stable-isotope-assisted NMR spectroscopy
Yoshiki Yamaguchi1, Koichi Kato
1Systems Glycobiology Research Group, Chemical Biology Department, RIKEN, Advanced Science Institute, Hirosawa, Wako, Japan.
Abstract:
Unique advantages offered by nuclear magnetic resonance (NMR) spectroscopy provide high-resolution information not only on structures but also on dynamics and interactions of glycoconjugates in solution. These benefits are further enhanced by applying stable-isotope-labeling techniques, which we have developed. Our stable-isotope-assisted NMR analyses of immunoglobulin G-Fc glycoproteins and the glycopeptides derived therefrom are here presented in terms of the dynamics and interactions of glycoconjugates.
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