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Updated: Jun 9, 2026

Exploring Protein-Glycan Interactions: Advances in Nuclear Magnetic Resonance
Published on: August 26, 2025
Intramolecular glycan-protein interactions in glycoproteins
Adam W Barb1, Andrew J Borgert, Mian Liu
1Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA.
Abstract:
Glycoproteins are a major class of glycoconjugates displaying a variety of mutual interactions between glycan and protein moieties that ultimately affect molecular organization. Modulation of the pendant glycan structures is important in tuning the functions of glycoproteins. Here we discuss structural aspects and some of the challenges to studying intramolecular interactions between carbohydrate and protein elements in several forms of O-linked as well as N-linked glycoproteins. These illustrate the importance of the relationship of context to function in protein glycosylation.
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