Related Experiment Video
Updated: Jun 9, 2026

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
Published on: June 28, 2018
Ventilator-associated pneumonia: a review.
Noyal Mariya Joseph1, Sujatha Sistla, Tarun Kumar Dutta
1Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India. noyaljoseph@yahoo.com
Ventilator-associated pneumonia (VAP) is a common ICU infection. This review covers recent advances in VAP definition, risk factors, diagnosis, treatment, and prevention for critically ill patients.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Pulmonology
Background:
- Ventilator-associated pneumonia (VAP) is the most common intensive-care-unit (ICU)-acquired infection.
- Critically ill patients face a high risk of nosocomial infections like VAP.
- VAP significantly contributes to patient morbidity, mortality, and increased healthcare costs.
Purpose of the Study:
- To provide a comprehensive review of ventilator-associated pneumonia (VAP).
- To highlight recent advancements in understanding and managing VAP.
- To cover key aspects including definition, risk factors, etiology, diagnosis, treatment, and prevention.
Main Methods:
- Literature review of existing studies on VAP.
- Synthesis of current knowledge on VAP pathogenesis and epidemiology.
- Emphasis on recent research and clinical guidelines.
Main Results:
- VAP incidence varies widely (6-52%) across ICUs.
- Multiple risk factors contribute to VAP development in critically ill patients.
- Significant progress has been made in understanding VAP etiology and management.
Conclusions:
- VAP remains a critical challenge in intensive care settings.
- A thorough understanding of VAP's multifaceted aspects is essential for effective control.
- Ongoing research and updated strategies are crucial for reducing VAP's impact.
Related Concept Videos
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia I: Introduction
Pneumonia V: Nursing management and Prevention
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed.
Pneumonia III: Complications and Assessment
Pneumonia II: Pathophysiology
Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
