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Amantadine resistance in relation to the evolution of influenza A(H3N2) viruses in Iran

Jila Yavarian1, Talat Mokhtari Azad, Xiang Zheng

  • 1School of Public Health, Tehran University of Medical Sciences, Porsina Ave, Keshavarz Blv., Tehran, Iran. yavarian@tums.ac.ir

Antiviral Research
|September 7, 2010
PubMed

Insights

Influenza A virus resistance to amantadine increased in Iran. A specific mutation (Ser31Asn) in the M2 protein was identified as the cause of this drug resistance in circulating viruses.

Area of Science:

  • Virology
  • Infectious Diseases
  • Drug Resistance

Background:

  • Amantadine and rimantadine are aminoadamantanes used for Influenza A virus treatment.
  • Recent years have seen increased resistance to these antivirals, especially in Influenza A(H3N2) subtypes.

Purpose of the Study:

  • To investigate the prevalence and genetic basis of amantadine resistance in Influenza A(H3N2) viruses in Iran.
  • To analyze the M gene mutations associated with amantadine resistance.

Main Methods:

  • Viral sequencing of hemagglutinin, neuraminidase, and M genes.
  • Analysis of M2 protein mutations, specifically Ser31Asn.

Main Results:

  • An increase in amantadine resistance was observed in Influenza A(H3N2) viruses circulating in Iran between 2005-2007.
  • The Ser31Asn mutation in the M2 channel protein was identified as the primary cause of resistance.
  • Emergence of resistance correlated with global evolutionary trends of H3N2 viruses.

Conclusions:

  • Amantadine resistance is a growing concern for Influenza A(H3N2) in Iran.
  • The Ser31Asn mutation is a key marker for amantadine resistance.
  • Monitoring viral evolution is crucial for effective influenza treatment strategies.

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