Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
Strength of Cement01:20

Strength of Cement

Strength tests for cement are not performed directly on neat cement paste due to difficulty in obtaining consistent, reliable specimens. Instead, cement is typically tested in the form of cement-sand mortar.
For compressive strength tests, ASTM C 109-05 standards prescribe a cement-sand mix ratio of 1:2.75 and a water/cement ratio of 0.485 for making 2-inch cubes. These cubes are mixed, cast, and cured in saturated lime water at 23°C until testing. Flexural strength testing, outlined in ASTM C...
Relation Between Tensile Strength and Compressive Strength of Concrete01:30

Relation Between Tensile Strength and Compressive Strength of Concrete

Concrete is a fundamental building material, and understanding its strengths is crucial for construction projects. The relationship between its tensile and compressive strengths is intricate, showing that while these strengths are related, they do not increase at the same rate. Tensile strength's growth is slower and is affected by various factors such as the methods used for testing, the size and shape of the specimen, the texture of the aggregate used, and the moisture content of the concrete.
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...
Machines: Problem Solving I01:22

Machines: Problem Solving I

A toggle clamp is a mechanical device commonly used for holding and clamping objects in various applications, such as woodworking, metalworking, and assembly operations. Consider a toggle clamp subjected to a force of 200 N at the handle. The vertical clamping force can be calculated, provided the dimensions of the toggle clamp are known.
The toggle clamp system is a machine structure consisting of movable, pin-connected multi-force members that form a stabilized system to transmit forces. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perioperative anesthetic management in pediatric heart transplantation: a single-center descriptive study involving 27 patients.

Frontiers in pediatrics·2026
Same author

Projected Changes in Yield and Water Use Efficiency of Cold-Region Rice and the Role of CO<sub>2</sub> Under Climate Change.

Plants (Basel, Switzerland)·2026
Same author

Pulse-duration dependence of electron acceleration and betatron radiation in tightly focused laser wakefield acceleration.

Optics express·2026
Same author

Synchrotron Radiation X‑ray Scattering Approaching Real Industrial Processing of Polymer.

Polymer science & technology (Washington, D.C.)·2026
Same author

Absence of Association Between Glaucoma and Stroke Risk: Insights From a Cross-Sectional Study and a Two-Sample Mendelian Randomization Study.

Journal of ophthalmology·2026
Same author

Comparative predictive value of the cholesterol-high-density lipoprotein-glucose index versus the triglyceride-glucose index for gestational dysglycemia: a two-cohort study.

Frontiers in endocrinology·2026

Related Experiment Video

Updated: Jun 9, 2026

The Quantification of Injectability by Mechanical Testing
04:46

The Quantification of Injectability by Mechanical Testing

Published on: May 13, 2020

Effect of force feeder on tablet strength during compression.

Ajit S Narang1, Venkatramana M Rao, Hang Guo

  • 1Bristol-Myers Squibb, Co., One Squibb Dr., PO Box 191, New Brunswick, NJ 08903-0191, United States. ajit.narang@bms.com

International Journal of Pharmaceutics
|September 7, 2010
PubMed
Summary

Tablet compression speed impacts tablet strength. Higher turret and force feeder speeds reduce tablet tensile strength and tabletability, offering insights for tablet press scale-up.

More Related Videos

Formation of Dispersible Taohong Siwu Tablets
05:44

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

Finite Element Modeling for the Simulation of the Quasi-Static Compression of Corrugated Tapered Tubes
06:34

Finite Element Modeling for the Simulation of the Quasi-Static Compression of Corrugated Tapered Tubes

Published on: January 6, 2023

Related Experiment Videos

Last Updated: Jun 9, 2026

The Quantification of Injectability by Mechanical Testing
04:46

The Quantification of Injectability by Mechanical Testing

Published on: May 13, 2020

Formation of Dispersible Taohong Siwu Tablets
05:44

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

Finite Element Modeling for the Simulation of the Quasi-Static Compression of Corrugated Tapered Tubes
06:34

Finite Element Modeling for the Simulation of the Quasi-Static Compression of Corrugated Tapered Tubes

Published on: January 6, 2023

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Tablet mechanical strength is a critical quality attribute influenced by formulation and manufacturing processes.
  • Understanding the impact of compression parameters is essential for consistent tablet production.

Purpose of the Study:

  • To investigate the effect of compression process variables on tablet tensile strength and tabletability.
  • To develop a scale-independent model for predicting tabletability based on process parameters.

Main Methods:

  • Utilized a model formulation for tablet compression studies.
  • Varied turret speed and force feeder speed during compression.
  • Derived a dimensionless equation (shear number) to quantify force feeder shear.
  • Evaluated scale-independence of tabletability-shear number relationship across different tablet presses (6-station Korsch, 16-station Betapress, 35-station Korsch XL-400).

Main Results:

  • Increased turret and force feeder speeds led to decreased tablet tensile strength and tabletability.
  • Turret speed influenced tabletability via dwell time and granule consolidation kinetics.
  • Force feeder shear, quantified by a shear number, was linked to over-lubrication and reduced tabletability.
  • The relationship between tabletability and shear number demonstrated scale-independence across tested presses.

Conclusions:

  • Compression process variables significantly affect tablet mechanical properties.
  • A scale-independent relationship between tabletability and force feeder shear number was established.
  • This model provides a valuable tool for tablet development, scale-up, and tablet press interchangeability.