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Updated: Jun 9, 2026

Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury
Published on: February 23, 2014
The culture of olfactory ensheathing cells (OECs)--a distinct glial cell type
Jennifer R Higginson1, Susan C Barnett
1Institute of Infection, Immunity and Inflammation College of Medical, Veterinary & Life Sciences, Glasgow Biomedical Research Centre, 120 University Place, Glasgow, UK.
Abstract:
Olfactory ensheathing cells (OECs) have become a popular candidate for the transplant-mediated repair of the damaged CNS. In this review a description is made of the origins of these cells and a historical development of their purification and maintenance in culture. In addition, we illustrate the cellular and molecular characteristics of OECs and emphasise that although they share many properties with Schwann cells, they possess several inherent differences which may allow them to be more beneficial for CNS repair. In summary, OECs are distinct glial cells and the detailed understanding of their biological and molecular properties is essential in ensuring their clinical efficacy after cell transplantation. This article is part of a Special Issue entitled: Understanding olfactory ensheathing glia and their prospect for nervous system repair.
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