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Related Concept Videos

Working Memory01:24

Working Memory

Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this information.
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...

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Exploring intermediate phenotypes with EEG: working memory dysfunction in schizophrenia.

Corinna Haenschel1, David Linden

  • 1Wales Institute of Cognitive Neuroscience, School of Psychology, Adeilad Brigantia, Bangor University, Gwynedd LL57 2AS, UK. c.haenschel@bangor.ac.uk

Behavioural Brain Research
|September 7, 2010
PubMed
Summary
This summary is machine-generated.

Schizophrenia research reveals that altered brain oscillations may underlie working memory deficits. Early sensory processing and neurotransmitter systems are implicated, guiding new treatment strategies.

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Area of Science:

  • Neuropsychology
  • Neurophysiology
  • Schizophrenia Research

Background:

  • Schizophrenia is associated with significant working memory impairments, particularly in visual processing.
  • Changes in oscillatory neural activity, measured via electroencephalography (EEG) and magnetoencephalography (MEG), are frequently observed in schizophrenia patients.
  • The interplay between cognitive deficits and neural oscillations in schizophrenia remains an active area of investigation.

Purpose of the Study:

  • To synthesize recent findings on working memory deficits and altered neural oscillations in schizophrenia.
  • To explore the potential link between oscillatory changes and working memory impairments.
  • To investigate the contribution of early sensory mechanisms and neurotransmitter systems to these deficits.

Main Methods:

  • Review of existing literature on working memory, oscillatory activity (EEG/MEG), and schizophrenia.
  • Analysis of studies investigating early sensory processing in schizophrenia.
  • Examination of the relationship between neurotransmitter systems (dopamine, GABA, glutamate, acetylcholine) and observed cognitive and neural alterations.

Main Results:

  • Evidence suggests that altered neural oscillations contribute to working memory deficits in schizophrenia.
  • Early sensory processing mechanisms appear to play a more significant role in cognitive deficits than previously recognized.
  • Links are established between working memory, neural oscillations, and key neurotransmitter systems in schizophrenia.

Conclusions:

  • Altered oscillatory activity is a potential mechanism underlying working memory deficits in schizophrenia.
  • Early sensory processing deficits are crucial factors in schizophrenia's cognitive and neural alterations.
  • Understanding these links provides a foundation for developing novel, potentially translatable, remediation strategies for schizophrenia.