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Related Experiment Video

Updated: Jun 9, 2026

Simultaneous Assessment of Kinship, Division Number, and Phenotype via Flow Cytometry for Hematopoietic Stem and Progenitor Cells

Simultaneous Assessment of Kinship, Division Number, and Phenotype via Flow Cytometry for Hematopoietic Stem and Progenitor Cells

Published on: March 24, 2023

Methods to assess stem cell lineage, fate and function.

Patricia K Nguyen¹, Divya Nag, Joseph C Wu

¹Department of Medicine, Stanford University School of Medicine, CA 94305, USA.

Advanced Drug Delivery Reviews

|September 7, 2010

Summary

This summary is machine-generated.

Stem cell therapy offers tissue regeneration but requires cells to differentiate, survive, and engraft. This review covers methods to evaluate transplanted cell function for heart, nervous system, and pancreas repair.

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Last Updated: Jun 9, 2026

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Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors

Published on: July 8, 2012

Area of Science:

Regenerative Medicine
Cell Biology
Biomedical Engineering

Background:

Stem cell therapy holds promise for tissue regeneration.
Successful therapeutic outcomes depend on cell differentiation, survival, and engraftment at injury sites.
Comprehensive evaluation of transplanted cells is crucial for assessing therapeutic efficacy.

Purpose of the Study:

To review methods for evaluating transplanted cell function in regenerative medicine.
To discuss the assessment of cell morphology, lineage markers, function, and gene expression.
To highlight challenges in evaluating stem cell therapy for cardiac, neural, and pancreatic repair.

Main Methods:

Cell fate imaging for monitoring survival and engraftment.
Assessment of cell morphology and lineage-specific markers.
Evaluation of cell-specific function and gene expression profiles.

Main Results:

Various methods exist to characterize transplanted stem cells.
Cell fate imaging is vital for tracking cell survival and engraftment.
Organ-specific function evaluation is key to determining therapeutic success.

Conclusions:

Effective stem cell therapy requires rigorous evaluation of cell behavior and function.
Specific challenges exist for cardiac, neural, and pancreatic regenerative medicine applications.
Further research is needed to optimize stem cell engraftment and functional integration.