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Updated: Jun 9, 2026
07:29
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Mechanisms of LDL oxidation
Hiroshi Yoshida1, Reiko Kisugi
1Department of Laboratory Medicine, Jikei University Kashiwa Hospital, Chiba, Japan. hyoshida@jikei.ac.jp
Clinica Chimica Acta; International Journal of Clinical Chemistry
|September 7, 2010
Summary
Oxidized low-density lipoprotein (LDL) plays a key role in atherosclerosis. Understanding LDL oxidation mechanisms is crucial for developing new treatments for cardiovascular diseases.
Area of Science:
- Cardiovascular Science
- Biochemistry
- Pathogenesis Research
Background:
- Accumulating evidence implicates oxidized low-density lipoprotein (oxLDL) in the development of atherosclerotic vascular diseases.
- This review focuses on the various proposed mechanisms of LDL oxidation, central to the LDL oxidation hypothesis of atherogenesis.
Purpose of the Study:
- To review and synthesize current knowledge on the mechanisms of LDL oxidation and its role in atherogenesis.
- To highlight gaps in understanding regarding physiologically relevant pathways of LDL oxidation.
Main Methods:
- Literature review of existing research on LDL oxidation.
- Analysis of research findings related to LDL oxidation catalysts and pathways.
Main Results:
- LDL oxidation is catalyzed by transition metal ions, free radicals, and oxidizing enzymes.
- Oxidized LDL is recognized by macrophage scavenger receptors, promoting foam cell formation and fatty streak lesions.
Conclusions:
- Multiple in vitro and in vivo pathways contribute to LDL oxidation.
- Physiologically relevant mechanisms of LDL oxidation remain incompletely understood.
- Further exploration of LDL oxidation mechanisms is essential for advancing atherosclerosis diagnosis and treatment.
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