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Updated: Jun 9, 2026

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

Curcumin nanodisks: formulation and characterization.

Mistuni Ghosh¹, Amareshwar T K Singh, Wenwei Xu

¹Department of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, California, USA.

Nanomedicine : Nanotechnology, Biology, and Medicine

|September 7, 2010

Summary

This summary is machine-generated.

Nanodisks (NDs) effectively encapsulate curcumin, enhancing its water solubility and delivery. Curcumin-loaded NDs show improved efficacy in inhibiting cancer cell growth and inducing apoptosis compared to free curcumin.

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Area of Science:

Biotechnology
Nanotechnology
Pharmacology

Background:

Nanodisks (NDs) are nanoscale, disk-shaped phospholipid bilayers stabilized by apolipoproteins.
Curcumin, a bioactive polyphenol, possesses therapeutic potential but suffers from poor water solubility and bioavailability.

Purpose of the Study:

To formulate and characterize nanodisks (NDs) loaded with curcumin.
To evaluate the efficacy of curcumin-loaded NDs in cancer cell lines.

Main Methods:

Nanodisks were formulated with curcumin at a 6:1 phospholipid-to-curcumin molar ratio.
Atomic force microscopy, absorbance, and fluorescence spectroscopy were used for characterization.
Cellular studies were performed using HepG2 cells and a mantle cell lymphoma model.

Main Results:

Curcumin-loaded NDs were characterized as particles <50 nm with enhanced water solubility and a distinct absorbance peak at 420 nm.
Fluorescence spectroscopy indicated curcumin self-quenching within NDs, which was relieved by redistribution.
Curcumin-NDs demonstrated enhanced cell growth inhibition in HepG2 cells and potent apoptosis induction in mantle cell lymphoma cells compared to free curcumin.

Conclusions:

Curcumin-loaded nanodisks offer improved curcumin delivery and therapeutic efficacy.
The nanoscale formulation enhances curcumin's anti-cancer properties, suggesting potential in vivo therapeutic applications.