Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Determination

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Adsorption characteristics of acetone and butanone onto honeycomb ZSM-5 molecular sieve].

Huan jing ke xue= Huanjing kexue·2014

Same author

[The research progress in determining lignocellulosic content by near infrared reflectance spectroscopy technology].

Guang pu xue yu guang pu fen xi = Guang pu·2014

Same author

Human papillomavirus prevalence is high in oral samples of patients with tonsillar and base of tongue cancer.

Oral oncology·2014

Same author

Neuroprotective effects of oxysophocarpine on neonatal rat primary cultured hippocampal neurons injured by oxygen-glucose deprivation and reperfusion.

Pharmaceutical biology·2014

Same author

Intertriginous cutaneous mastocytosis in a 16-year-old boy.

International journal of dermatology·2014

Same author

Lycium barbarum polysaccharide prevents focal cerebral ischemic injury by inhibiting neuronal apoptosis in mice.

PloS one·2014

Search research articles

Related Experiment Video

Updated: Jun 9, 2026

Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis

Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis

Published on: April 1, 2022

Expression of Dpp6 in mouse embryonic craniofacial development.

Juan Du¹, Zhipeng Fan, Xin Ma

¹Molecular Laboratory for Gene Therapy and Tooth Regeneration, Capital Medical University School of Stomatology, Beijing, PR China.

Acta Histochemica

|September 7, 2010

Summary

Dipeptidyl-peptidase-like protein 6 (DPP6) is newly found to be expressed in developing mouse craniofacial structures. Its expression pattern suggests DPP6 may play a role in embryonic craniofacial development.

More Related Videos

Separation of Mouse Embryonic Facial Ectoderm and Mesenchyme

Separation of Mouse Embryonic Facial Ectoderm and Mesenchyme

Published on: April 12, 2013

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

Related Experiment Videos

Last Updated: Jun 9, 2026

Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis

Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis

Published on: April 1, 2022

Separation of Mouse Embryonic Facial Ectoderm and Mesenchyme

Separation of Mouse Embryonic Facial Ectoderm and Mesenchyme

Published on: April 12, 2013

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

Area of Science:

Developmental Biology
Genetics

Background:

Dipeptidyl-peptidase-like protein 6 (DPP6) is known for its roles in brain development.
Its involvement in embryonic craniofacial development remains uncharacterized.

Purpose of the Study:

To investigate the expression pattern of Dpp6 during embryonic craniofacial development in mice.
To explore the potential role of Dpp6 in maxillofacial development.

Main Methods:

Whole-mount in situ hybridization on sections was used to analyze Dpp6 expression.
Real-time PCR was employed to quantify Dpp6 expression levels.

Main Results:

Dpp6 expression was detected in the maxillofacial region of mouse embryos between 11 and 13.5 days post-coitum.
Quantitative analysis revealed high Dpp6 expression from 11.5 to 13.5 days post-coitum, followed by a decrease as development progressed.

Conclusions:

The temporal and spatial expression pattern of Dpp6 suggests a potential role in embryonic craniofacial development.
Further research is warranted to elucidate the specific functions of DPP6 in this process.