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Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Jun 9, 2026

Diagnostic Necropsy and Selected Tissue and Sample Collection in Rats and Mice
09:13

Diagnostic Necropsy and Selected Tissue and Sample Collection in Rats and Mice

Published on: August 7, 2011

Training pathologists in mouse pathology.

J P Sundberg1, J M Ward, H HogenEsch

  • 1The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609-1500, USA. john.sundberg@jax.org

Veterinary Pathology
|September 7, 2010
PubMed
Summary
This summary is machine-generated.

Expert mouse pathology has evolved beyond toxicologic pathology to specialized research pathobiology. Comprehensive training is crucial for pathologists supporting genetically engineered mouse models in biomedical research.

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Area of Science:

  • Veterinary Pathology
  • Pathobiology
  • Biomedical Research

Background:

  • Mouse pathology expertise has expanded from toxicologic pathology to specialized research pathobiology.
  • The increasing use of genetically modified mice necessitates advanced pathobiological understanding.
  • Expert mouse pathologists are vital for basic and translational biomedical research success.

Purpose of the Study:

  • To highlight the evolution of mouse pathology expertise.
  • To emphasize the critical role of specialized mouse pathologists in modern research.
  • To discuss the necessary training components for research-oriented mouse pathologists.

Main Methods:

  • Analysis of the expanding scope of mouse pathobiology.
  • Evaluation of training requirements beyond traditional veterinary pathology.
  • Consideration of genetically engineered mouse models and complex trait analysis.

Main Results:

  • Traditional toxicologic pathology is insufficient for current research needs.
  • Research pathobiology requires expertise in genetics, nomenclature, and genetic engineering.
  • Existing training programs (apprenticeships) are often service-heavy and lack comprehensive scope.

Conclusions:

  • Training must encompass specialized genetic nomenclature, husbandry, and genetic engineering.
  • Specialty courses and expert mentoring are essential for developing cutting-edge skills.
  • Active practice and publication are key to acquiring expertise in mouse-based experimental science.