Related Experiment Video
Updated: Jun 9, 2026

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development
Published on: April 3, 2013
Go or stop? Divergent roles of Reelin in radial neuronal migration
Shanting Zhao1, Michael Frotscher
1Institute of Anatomy and Cell Biology, University of Freiburg, Freiburg, Germany.
Abstract:
Neuronal migration is an essential step of brain development and is controlled by a variety of cellular proteins and extracellular matrix molecules. Reelin, an extracellular matrix protein, is required for neuronal migration. Over the past 10 years, the Reelin signaling cascade has been studied intensively. However, the role of Reelin in neuronal migration has remained unclear. Different Reelin fragments and different Reelin receptors suggest multiple functions of Reelin. In this review, the authors focus on Reelin effects on the actin cytoskeleton of migrating neurons.
Related Concept Videos
Cell Polarization by Rho Proteins
Cytoskeletal Coordination in Cell Migration
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
Cell Migration
Cell Migration
Role Of Notch Signalling In Intestinal Stem Cell Renewal
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

