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Updated: Jun 9, 2026
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Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
Published on: November 17, 2014
Improved conjunctival transplantation for corneal ulcer
Qinghua Zhou1, Xianhua Long, Xiaohua Zhu
1Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha 410008, China. zhouqh1975@yahoo.com.cn
Summary
Pedicle conjunctival flap transposition effectively treats refractory corneal ulcers, with a high success rate and preserved globes. This surgical technique offers significant therapeutic benefits for severe eye conditions.
Area of Science:
- Ophthalmology
- Surgical Techniques
- Corneal Diseases
Background:
- Refractory corneal ulcers pose a significant challenge in ophthalmology.
- Effective treatment options are crucial for preserving vision and ocular integrity.
Purpose of the Study:
- To evaluate the therapeutic efficacy of pedicle conjunctival flap transposition for refractory corneal ulcers.
- To assess the outcomes and complication rates associated with this surgical procedure.
Main Methods:
- Retrospective analysis of 56 patients with refractory corneal ulcers treated between June 2005 and June 2009.
- All patients underwent focal debridement and pedicle conjunctival flap transposition.
- Included ulcers were infective, keratoplasty graft, traumatic, and chemical burn related.
Main Results:
- An overall success rate of 83.9% (47/56) was achieved after the initial surgery.
- Conjunctival flap retraction occurred in 8.9% of cases, with some requiring additional surgeries.
- Four patients (7.2%) experienced fungal corneal ulcer relapse and proceeded to lamellar keratoplasty.
- Ocular integrity was preserved in 52 patients, with varying degrees of visual improvement.
Conclusions:
- Pedicle conjunctival flap transposition is a highly effective surgical intervention for refractory corneal ulcers.
- The procedure demonstrates a favorable safety profile with a high rate of globe preservation.
- It offers a viable treatment option for complex corneal pathologies unresponsive to other therapies.
