[Treating superficial hemangioma in children according to local blood flow]

Ranglang Huang1, Wanpin Nie, Xianjie Cheng

  • 1General Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China.

Insights

Injection therapy effectively treats superficial hemangioma in children. Individualized treatment based on local blood flow velocity ensures high cure rates for pediatric hemangioma.

Area of Science:

  • Pediatric Dermatology
  • Vascular Anomalies

Background:

  • Superficial hemangiomas are common benign vascular tumors in infants and children.
  • Treatment decisions for pediatric hemangioma often depend on lesion characteristics and potential complications.

Purpose of the Study:

  • To evaluate the efficacy of injection therapy for superficial hemangioma in children.
  • To determine the impact of local blood flow velocity on treatment outcomes.

Main Methods:

  • Analysis of clinical data from 98 children with superficial hemangiomas treated between January 2005 and June 2009.
  • Treatment strategies, including injection therapy and combined injection with surgery, were tailored based on local blood flow velocity.

Main Results:

  • Ninety-four out of 98 children (95.9%) achieved a complete cure.
  • Treatment success was correlated with individualized approaches based on local hemodynamics.

Conclusions:

  • Injection therapy demonstrates significant effectiveness in treating pediatric superficial hemangioma.
  • Personalized treatment plans, guided by local blood flow assessment, are crucial for optimizing outcomes in children with hemangioma.
Abstract

Related Concept Videos

Blood Flow01:29

Blood Flow

Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...