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Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
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Reproducibility-repeatability of choroidal thickness calculation using optical coherence tomography.

Alexandra Benavente-Pérez1, Sarah L Hosking, Nicola S Logan

  • 1Department of Biological Sciences, SUNY State College of Optometry, New York, New York 10036, USA. abenavente@sunyopt.edu

Optometry and Vision Science : Official Publication of the American Academy of Optometry
|September 7, 2010
PubMed
Summary

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Manual optical coherence tomography (OCT) measurements of subfoveal choroidal thickness (CT) in healthy eyes are repeatable and reproducible. This supports OCT

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Retinal Imaging

Background:

  • Accurate measurement of subfoveal choroidal thickness (CT) is crucial for diagnosing and monitoring retinal diseases.
  • Manual CT calculations using optical coherence tomography (OCT) require evaluation for reliability.

Purpose of the Study:

  • To assess the repeatability and reproducibility of manual subfoveal choroidal thickness (CT) measurements using spectral domain optical coherence tomography (OCT).

Main Methods:

  • Healthy volunteers underwent OCT imaging over two visits.
  • Subfoveal CT was manually calculated from radial scans using ImageJ processing filters.
  • Repeatability and reproducibility were quantified using variability coefficients, coefficient of repeatability (CoR), coefficient of reproducibility, and intraclass correlation coefficient.

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  • Axial length (AL) and refractive error were measured to explore their relationship with CT.

    • Main Results:

    • High repeatability and reproducibility were observed for manual subfoveal CT measurements (e.g., CoR of 2.97% within-visit, 2.44% between-visit).
    • A significant negative correlation was found between subfoveal CT and axial length (AL) (R = -0.60, p = 0.05).

    Conclusions:

    • Manual subfoveal CT measurements using OCT are repeatable and reproducible in vivo.
    • OCT is a potentially valuable tool for in vivo assessment and monitoring of CT changes in retinal diseases.
    • Subfoveal CT appears to decrease with increasing axial length, but not with refractive error.