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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...

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Related Experiment Video

Updated: Jun 9, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

Algorithm for the management of osteoporosis.

Ronald C Hamdy1, Sanford Baim, Susan B Broy

  • 1Department of Geriatric Medicine and Gerontology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA. smjedit@etsu.edu

Southern Medical Journal
|September 7, 2010
PubMed
Summary

Osteoporosis, a common bone-weakening disease, often goes untreated even after fractures. This study introduces an algorithm to help clinicians efficiently manage osteoporosis and improve patient outcomes.

Related Experiment Videos

Last Updated: Jun 9, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

Area of Science:

  • Geriatrics
  • Orthopedics
  • Endocrinology

Background:

  • Osteoporosis is a prevalent skeletal disease leading to weakened bones and increased fracture risk, affecting a significant portion of older adults.
  • Despite effective prevention, diagnosis, and management strategies, many osteoporosis cases remain unrecognized or undertreated, even post-fracture.
  • Suboptimal patient adherence to medication regimens compromises treatment efficacy in reducing fracture risk.

Purpose of the Study:

  • To present a clinical algorithm designed to streamline osteoporosis management for busy healthcare providers.
  • To facilitate the efficient and state-of-the-art care of patients diagnosed with osteoporosis.

Main Methods:

  • Development of a clinical practice algorithm for osteoporosis prevention and treatment.
  • Focus on integrating National Osteoporosis Foundation (NOF) guidelines into clinical workflow.
  • Algorithm designed to address challenges in clinician time constraints and patient adherence.

Main Results:

  • The proposed algorithm aims to improve the efficiency of osteoporosis diagnosis and management.
  • It seeks to enhance the utilization of clinical practice guidelines by healthcare providers.
  • The tool is intended to support clinicians in providing optimal care and improving patient outcomes.

Conclusions:

  • An efficient algorithm can aid clinicians in overcoming barriers to optimal osteoporosis care.
  • Streamlining management protocols can lead to better patient outcomes and fracture risk reduction.
  • Improved adherence and timely intervention are crucial for managing osteoporosis effectively.