Related Experiment Video
Updated: Jun 9, 2026

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
Published on: June 8, 2020
Continue or discontinue warfarin for fecal occult blood testing in 2010? Does the published evidence provide an
1Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Abstract:
Whether to continue or discontinue warfarin before fecal occult blood testing (FOBT) requires comparison of the risks and benefits of both choices. Clinical practice varies on this issue, and guidelines are silent. A small body of evidence about the effect of warfarin on test characteristics of FOBT is inconclusive, although it suggests no effect. Retrospective studies on this topic may be prone to transfer bias, which affects the composition of the groups assembled for study. Considering the risks and benefits of discontinuing warfarin qualitatively, along with the published literature and clinical context in 2010, where tolerance for false-positive results is higher than it used to be and where immunochemical FOBT is a better screening test than older, guaiac-based FOBT, "no" seems like the "commonsense" answer.
Related Concept Videos
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Venous Thrombosis III: Interprofessional Care
Serum Laboratory Studies, Stool Test, Breath Test
Venous Thrombosis IV: Nursing Management
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Anticoagulant Drugs: Low-Molecular-Weight Heparins
