Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sensory-selective Sciatic Nerve Block with 2',6' Pipecolylxylidine in an Ovine Model.

Anesthesiology·2026
Same author

Sensory-selective Peripheral and Neuraxial Nerve Blockade with 2',6'-Pipecoloxylidide: Erratum.

Anesthesiology·2026
Same author

Polymeric rapamycin nanoparticles encapsulating ponatinib cause regression of venous malformations in mice.

Science translational medicine·2026
Same author

Polyketal-conjugated tafluprost microparticles enable long-acting glaucoma therapy.

Nature communications·2026
Same author

Extruded droplet-on-demand (X-DoD) bioprinting for controlled iPSC-based functional cortical network formation.

Biofabrication·2026
Same author

Precise Spatiotemporal Control of Sensory Nerve Blockade via Light-Triggered Click-Release Uncaging of 2',6'-Pipecoloxylidide.

Angewandte Chemie (International ed. in English)·2026
Same journal

Integrated Electrode-to-Device Design via Combination of Grain Boundary Reconstruction and Dynamic Gas Management Toward Stable 3 Ah Aqueous Zinc-Iodine Pouch Cells.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Diblock Copolymer Engineered Swim Bladder Membrane Enables Spatiotemporal Synchronized Defense and Pro-Healing in Challenging Soft Tissue Regeneration.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Solvation Chemistry Reimagined: LiPF6-Enabled Suppression of Gas Evolution for Ultra-Stable 200 Ah Anode-Free Lithium-Metal Batteries.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Entropy-Driven Conformational Disorder Enables Outstanding High-Temperature Energy Storage in Dielectric Polymers.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Breaking Thermal Conductivity-Electrical Resistivity Trade-Off in Liquid Metal-Based Thermal Interface Materials via Interface Engineering.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Screen-Printed Few-Layer Graphene Platforms for Monitoring Switchable Spin-Crossover Phenomena at Room-Temperature.

Advanced materials (Deerfield Beach, Fla.)·2026
See all related articles

Related Experiment Video

Updated: Jun 9, 2026

Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
11:51

Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models

Published on: August 16, 2010

Remotely triggerable drug delivery systems.

Brian P Timko1, Tal Dvir, Daniel S Kohane

  • 1Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

Advanced Materials (Deerfield Beach, Fla.)
|September 7, 2010
PubMed
Summary
This summary is machine-generated.

New triggerable drug delivery systems offer controlled release activated by external stimuli like light or magnetic fields. These advanced materials enhance therapeutic effectiveness and minimize side effects for better patient outcomes.

More Related Videos

Osmotic Pump-based Drug-delivery for In Vivo Remyelination Research on the Central Nervous System
06:07

Osmotic Pump-based Drug-delivery for In Vivo Remyelination Research on the Central Nervous System

Published on: December 17, 2021

Related Experiment Videos

Last Updated: Jun 9, 2026

Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
11:51

Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models

Published on: August 16, 2010

Osmotic Pump-based Drug-delivery for In Vivo Remyelination Research on the Central Nervous System
06:07

Osmotic Pump-based Drug-delivery for In Vivo Remyelination Research on the Central Nervous System

Published on: December 17, 2021

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Controlled drug release is crucial for enhancing therapeutic efficacy and reducing systemic toxicity.
  • Traditional drug delivery methods often lack precise control over dose and timing.
  • Recent advancements focus on stimuli-responsive materials for on-demand drug release.

Purpose of the Study:

  • To review emerging triggerable materials for controlled drug delivery.
  • To explore materials responsive to various external stimuli.
  • To highlight the potential of these systems in clinical applications.

Main Methods:

  • Literature review of recent research on triggerable drug delivery systems.
  • Categorization of materials based on responsive stimuli (visible light, NIR light, ultrasound, magnetic fields).
  • Analysis of material scale from nano to macro.

Main Results:

  • Development of diverse materials sensitive to external triggers.
  • Demonstration of remote activation for precise control over drug release.
  • Materials responsive to visible light, NIR, ultrasound, and magnetic fields are available.
  • Systems range from nanoscale to macroscale.

Conclusions:

  • Triggerable drug delivery systems offer significant advantages in therapeutic control.
  • Remote activation by external stimuli allows for flexible dose management.
  • These advanced materials hold promise for improved treatment strategies and reduced patient toxicity.