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Potential of Baliospermum montanum against compound 48/80-induced systemic anaphylaxis
P Venkatesh1, Pulok K Mukherjee, Debajyoti Mukherjee
1School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.
Context:
Decoctions of Baliospermum montanum Müll. Arg. (Euphorbiaceae) leaves are reported to be useful in the treatment of asthma and other respiratory complications in the Ayurvedic system.
Objective:
To evaluate the mast cell stabilization and antihistaminic activities of the chloroform (BMLC) and ethanol (BMLE) extracts of the leaves of Baliospermum montanum.
Materials And Methods:
The stabilization potential was studied on mouse peritoneal mast cells and the antihistaminic activity was carried out by determining the mortality rate of mice treated with toxicant (compound 48/80) and the effect on elevation of histamine release upon degranulation.
Results:
The increased number of intact mast cells (43.640 ± 1.7% and 61.57 ± 1.79% at 200 and 400 mg/ kg, respectively) suggested that the BMLC stabilized the mast cell degranulation and showed decreased elevation of histamine.
Conclusion:
BMLC extract was found to be most effective against degranulation and release of histamine from mast cells. Identifying the lead from this plant will be a definite target for treating allergic diseases.
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