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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
08:49

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

Published on: January 22, 2019

TRAIL receptor signaling and therapeutics

Junaid Abdulghani1, Wafik S El-Deiry

  • 1Penn State Hershey Medical Center, Penn State Hershey Cancer Institute, Penn State College of Medicine, Department of Medicine (Hematology/Oncology), Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Hershey, PA 17033, USA.

Expert Opinion on Therapeutic Targets
|September 8, 2010
PubMed
Abstract

Insights

TNF-related apoptosis-inducing ligand (TRAIL) therapies show promise for targeted cancer treatment by inducing apoptosis. Combination strategies can overcome TRAIL resistance, enhancing therapeutic potential.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in tumor cells via TRAIL-R1/R2, with low normal cell toxicity.
  • Development focuses on receptor-specific TRAIL variants and agonistic antibodies to activate death-receptor pathways, avoiding decoy receptor interference.
  • TRAIL-based therapies are advancing in clinical trials for cancer treatment.

Purpose of the Study:

  • To review recent advances in TRAIL-based cancer therapies, including receptor-specific variants and agonistic antibodies.
  • To discuss combination therapies aimed at overcoming TRAIL resistance in cancer cells.
  • To provide insights into current clinical trials and future prospects of TRAIL signaling pathway-targeting therapies.

Main Methods:

  • Review of recent advancements in TRAIL and agonistic antibody development for cancer therapy.
  • Discussion of combination strategies to enhance TRAIL efficacy and overcome resistance.
  • Analysis of data from ongoing clinical trials involving TRAIL-targeting agents.

Main Results:

  • Several TRAIL variants and agonistic antibodies targeting TRAIL-R1/R2 are in clinical trials.
  • Combination therapies involving TRAIL or antibodies with chemotherapy, targeted agents, or irradiation can sensitize resistant tumors.
  • Understanding of TRAIL signaling pathways is crucial for overcoming therapeutic obstacles.

Conclusions:

  • Targeting the TRAIL/TRAIL receptor pathway offers a promising strategy for molecularly targeted, pro-apoptotic cancer therapy.
  • Further research and clinical trials are essential to fully realize the potential of TRAIL-based treatments.
  • Combination approaches are key to overcoming resistance and improving outcomes in TRAIL-targeted cancer therapy.

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