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Aneuploid DNA content in pancreatic adenocarcinoma
T M Wido1, J L Myles, L Pisharodi
1Department of Pathology, Medical College of Ohio, Toledo 43699.
Abstract:
DNA content measurements were performed by flow cytometry on eight ductal-type pancreatic adenocarcinomas. The majority of the neoplasms contained an aneuploid DNA content, with hyperdiploid DNA content being the most common abnormality. Two neoplasms had a diploid DNA content. These latter two patients are alive at 11 mo and 3 mo. The data suggest that a large percentage of pancreatic adenocarcinomas have an aneuploid DNA content. Further study is needed to evaluate the relationship between aneuploid DNA content and survival.