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Updated: Jun 9, 2026
Oleic Acid-Injection in Pigs As a Model for Acute Respiratory Distress Syndrome
Published on: October 26, 2018
Effect of partial liquid ventilation on oleic acid-induced inflammatory responses in piglets
Yao-bin Zhu1, Qiang Wang, Ying-long Liu
1Department of Pediatric Cardiac Surgery Center, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Insights
Partial liquid ventilation (PLV) improves lung function and reduces inflammatory cytokines in piglets with acute lung injury (ALI). This protective effect highlights PLV as a potential treatment for pediatric ALI.
Area of Science:
- Pediatric critical care medicine
- Respiratory physiology
- Inflammatory response research
Background:
- Pediatric patients are vulnerable to acute lung injury (ALI), which carries a high mortality rate.
- Partial liquid ventilation (PLV) has demonstrated efficacy in improving oxygenation and reducing lung injury in various models.
- The study investigates PLV's impact on cytokine production in immature piglets with ALI.
Purpose of the Study:
- To test if PLV can reduce local and systemic cytokine production in piglets with oleic acid-induced ALI.
- To evaluate the protective effects of PLV in an immature animal model of lung injury.
Main Methods:
- Acute lung injury (ALI) was induced in twelve Chinese immature piglets using oleic acid (OA).
- Animals were divided into two groups: conventional mechanical ventilation (MV) and PLV with FC-77.
- Cardiopulmonary variables and cytokine levels (IL-1beta, IL-6, IL-10, TNF-alpha) in plasma and tissue were measured.
Main Results:
- The PLV group exhibited significantly improved cardiopulmonary variables compared to the MV group (P < 0.05).
- These improvements included heart rate, mean blood pressure, blood pH, PaO2, PaO2/FiO2, and PaCO2.
- PLV significantly reduced plasma and tissue concentrations of IL-1beta, IL-6, IL-10, and TNF-alpha (P < 0.05).
Conclusions:
- Partial liquid ventilation demonstrates significant protective effects against inflammatory responses in the lungs.
- PLV attenuates both local and systemic inflammatory cytokine production in a pediatric model of ALI.
- These findings suggest PLV is a promising therapeutic strategy for acute lung injury in pediatric patients.
Background:
Pediatric patients are susceptible to lung injury. Acute lung injury (ALI) in children often results in a high mortality. Partial liquid ventilation (PLV) has been shown to markedly improve oxygenation and reduce histologic evidence of injury in a number of lung injury models. This study aimed to examine the hypothesis that PLV would attenuate the production of local and systemic cytokines in an immature piglet model of ALI induced by oleic acid (OA).
Methods:
Twelve Chinese immature piglets were induced to develop ALI by oleic acid. The animals were randomly assigned to two groups (n = 6): (1) conventional mechanical ventilation (MV) group and (2) PLV with FC-77 (10 ml/kg) group.
Results:
Compared with MV group, PLV group got better cardiopulmonary variables (P < 0.05). These variables included heart rate, mean blood pressure, blood pH, partial pressure of arterial oxygen (PaO2), PaO2/FiO2 and partial pressure of arterial carbon dioxide (PaCO2). Partial liquid ventilation reduced IL-1beta, IL-6, IL-10 and TNF-alpha both in plasma and tissue concentrations compared with MV group (P < 0.05).
Conclusions:
Partial liquid ventilation provides protective effects against inflammatory responses in the lungs of oleic acid-induced immature piglets.
