Related Experiment Video
Updated: Jun 9, 2026

A Luciferase-fluorescent Reporter Influenza Virus for Live Imaging and Quantification of Viral Infection
Published on: August 14, 2019
Practice and child characteristics associated with influenza vaccine uptake in young children
Katherine A Poehling1, Gerry Fairbrother, Yuwei Zhu
1Wake Forest University Medical Center, Department of Pediatrics, Winston-Salem, NC 27157, USA. kpoehlin@wfubmc.edu
Insights
Pediatric influenza vaccination coverage in 2004-2005 was 27%. Key strategies for increasing childhood flu shots included evening/weekend vaccine clinics and scheduling visits between October and January.
Area of Science:
- Pediatrics
- Public Health
- Vaccinology
Background:
- The 2004-2005 influenza season marked the first year of universal influenza vaccination recommendations for children aged 6 to 23 months.
- Understanding factors influencing vaccine uptake is crucial for improving childhood immunization rates.
Purpose of the Study:
- To identify practice and child characteristics associated with influenza vaccine receipt in young children.
- To evaluate practice strategies that may enhance influenza vaccination coverage.
Main Methods:
- A community-based cohort study involved chart reviews of 2384 children aged 6 to 23 months across 3 US counties.
- Practices completed surveys to assess their characteristics and vaccination strategies.
- Multinomial logistic regression was used to determine predictors of complete influenza vaccination.
Main Results:
- Overall, 27% of eligible children received the influenza vaccine.
- Vaccination rates varied significantly among practices, ranging from 0% to 71%.
- Factors associated with higher vaccination rates included suburban practice location, lower patient volume, evening/weekend vaccine clinics, younger child age, presence of high-risk conditions, multiple well visits, and visits between October and January.
Conclusions:
- Modifiable practice-level factors, such as offering evening/weekend vaccine clinics and scheduling visits from October to January, are associated with increased influenza vaccination coverage in young children.
- Targeted strategies can help improve adherence to universal childhood influenza vaccination recommendations.
Objectives:
The objective of this study was to determine both practice and child characteristics and practice strategies associated with receipt of influenza vaccine in young children during the 2004-2005 influenza season, the first season for the universal influenza vaccination recommendation for all children who are aged 6 to 23 months.
Methods:
Clinical and demographic data from randomly selected children who were aged 6 to 23 months were obtained by chart review from a community-based cohort study in 3 US counties. The proportion of children who were vaccinated by April 5, 2005, in each practice was obtained. For assessment of practice characteristics and strategies, sampled practices received a self-administered practice survey. Practice and child characteristics that predicted complete influenza vaccination were determined by using multinomial logistic regression.
Results:
Forty-six (88%) of 52 sampled practices completed the survey and permitted chart reviews. Of 2384 children who were aged 6 to 23 months and were studied, 27% were completely vaccinated. The proportion of children who were completely vaccinated varied widely among practices (0%-71%). Most (87%) practices implemented ≥1 vaccination strategy. Complete influenza vaccination was associated with 3 practice characteristics: suburban location, lower patient volume, and vaccination strategies of evening/weekend vaccine clinics; with child characteristics of younger age, existing high-risk conditions, ≥6 well visits to the practice by 3 years of age, and any practice visit from October through January.
Conclusions:
Modifiable factors that were associated with increased influenza vaccination coverage included October to January practice visits and evening/weekend vaccine clinics.
Related Concept Videos
Vaccinations
Influenza
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Pharmacokinetics in Pediatric Patients: Drug Excretion
Respiratory Syncytial Virus Disease
Drug Dosing: Infants and Children

