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[The content of thiamine, its coenzyme form and activity of thiamine diphosphate-dependent enzymes in ontogenesis]
Ukrainskii Biokhimicheskii Zhurnal (1978)
|March 1, 1978
Insights
This study reveals thiamine levels in rat liver are lowest during embryonic development and peak after birth. These findings highlight a direct link between thiamine, its active forms, and key enzymes during development.
Area of Science:
- Biochemistry
- Developmental Biology
- Nutritional Science
Abstract:
In experiments on rats of different age it is shown that the lowest content of thiamine and its phosphoric ethers in the liver is typical of the early periods of embryonal development and the highest one of the first days after birth. A direct dependence is established between the content of thiamine, its coenzyme form, enzyme of thiamine diphosphate synthesis (thiamine pyrophosphokinase) and thiamine diphosphate-containing enzyme (transketolase) in the rat liver in different periods of ontogenesis.