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Targeting integrins in malignant glioma

Ghazaleh Tabatabai1, Michael Weller, Burt Nabors

  • 1Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, 8091 Zurich, Switzerland. ghazaleh.tabatabai@usz.ch

Targeted Oncology
|September 8, 2010
PubMed

Insights

Integrin inhibitors like cilengitide show promise for treating glioma. Clinical trials indicate durable remissions in glioblastoma (GBM) and potential synergy with standard therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Adhesion Research

Background:

  • Integrins are cell adhesion receptors implicated in cancer.
  • AlphaVbeta3 and alphaVbeta5 integrins are overexpressed in glioma and tumor vasculature.
  • Cilengitide is a leading integrin inhibitor in oncology.

Purpose of the Study:

  • To review the role of integrins in gliomagenesis.
  • To summarize the therapeutic potential of integrin inhibition for glioma.
  • To outline ongoing clinical trials for integrin inhibitors in GBM.

Main Methods:

  • Review of preclinical data on integrin function in glioma.
  • Analysis of clinical trial results for cilengitide in recurrent and newly diagnosed GBM.
  • Summary of ongoing phase III studies (e.g., CENTRIC).

Main Results:

  • Cilengitide demonstrates antitumor activity in glioma.
  • Durable remissions observed in Phase I/II trials for recurrent glioblastoma.
  • Encouraging results from pilot trials in newly diagnosed GBM with standard therapy.

Conclusions:

  • Integrin inhibition is a promising anticancer strategy for glioma.
  • Cilengitide shows potential for treating glioblastoma, particularly in combination therapy.
  • Ongoing trials will further define the efficacy of integrin inhibitors in GBM.

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