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Updated: Jun 9, 2026

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
Non-viral causes of hepatocellular carcinoma
David H Van Thiel1, Guiliano Ramadori
1Rush University Medical Center, Chicago, IL 60612, USA. david_vanthiel@rush.edu
Introduction:
Hepatocellular carcinoma (HCC) is a major cause of cancer worldwide. The vast majority of cases occur in individuals with a chronic HBV or HCV infection. In addition, a number of metabolic diseases of the liver are associated with the development of HCC.
Pathophysiologic Mechanisms:
The mechanisms responsible for the progression of the metabolic liver disease and HCC differ from those associated with viral liver disease.
Conclusions:
The purpose of this report is to describe the mechanisms responsible for the disease progression and HCC in case of metabolic liver disease. A secondary goal is to identify the frequency of HCC development in the disorders described.
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