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Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease
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Published on: May 13, 2010

Progress in the development of therapeutic antibodies targeting prion proteins and beta-amyloid peptides

JinSheng He1, Ying Zhang, Tao Hong

  • 1College of Life Sciences and Bioengineering, School of Science, Beijing Jiaotong University, Beijing, China. jshhe@bjtu.edu.cn

Science China. Life Sciences
|September 8, 2010
PubMed

Prion diseases and Alzheimer's disease (AD) are characterized by protein misfolding, and can lead to dementia. However, prion diseases are infectious and transmissible, while AD is not. The similarities and differences between these diseases have led researchers to perform comparative studies. In the last 2 decades, progress has been made in immunotherapy using anti-prion protein and anti-beta-amyloid antibodies. In this study, we review new ideas and strategies for therapeutic antibodies targeting prion diseases and AD through conformation dependence.

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