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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation
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MRI of stroke using hyperpolarized 129Xe.

Xin Zhou1, Yanping Sun, Mary Mazzanti

  • 1State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China. dr.xin.zhou@gmail.com

NMR in Biomedicine
|September 8, 2010
PubMed
Summary

Hyperpolarized xenon-129 MRI can detect stroke-related hypoperfusion in the brain. This novel technique images cerebral blood flow deficits, offering a new tool for stroke research.

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Area of Science:

  • Medical Imaging
  • Neuroscience
  • Biophysics

Background:

  • Xenon has no background signal in biological tissues.
  • Hyperpolarized xenon (HP Xe) can serve as a tracer for cerebral blood flow.
  • Stroke causes perfusion deficits, reducing xenon concentration in affected brain regions.

Purpose of the Study:

  • To investigate the utility of hyperpolarized (129)Xe MRI in detecting cerebral perfusion deficits in a stroke model.
  • To establish HP Xe MRI as a tool for imaging focal cerebral ischemia.
  • To explore the application of HP Xe MRI in studying brain hypoperfusion.

Main Methods:

  • Utilized a rat permanent right middle cerebral artery occlusion model.
  • Employed hyperpolarized (129)Xe MRI to image cerebral blood flow.
  • Compared HP Xe MRI findings with proton MRI for stroke pathophysiology.

Main Results:

  • HP Xe MRI successfully detected the hypoperfused area in a rat model of focal cerebral ischemia (stroke).
  • The study demonstrated the ability of HP Xe MRI to visualize the ischemic core region.
  • This marks the first use of HP Xe MRI for exploring normal and abnormal cerebral perfusion.

Conclusions:

  • Hyperpolarized (129)Xe MRI is a novel and effective method for imaging stroke-induced hypoperfusion.
  • HP Xe MRI can serve as a complementary tool to proton MRI for studying brain hypoperfusion.
  • This technique offers new insights into the pathophysiology of stroke and related conditions.