Related Experiment Videos
[Transient hyperphosphatasemia in infants]
R Colli1, G Frigerio, G A Bianchi
1Divisione di Pediatria, USSL n. 61, Carate Brianza, Milano.
Insights
Transient elevations in serum alkaline phosphatase were observed in two infants. This bone and liver enzyme increase, lasting 4-6 weeks, may be linked to infection and warrants awareness to prevent unnecessary tests.
Area of Science:
- Pediatric Medicine
- Biochemistry
- Clinical Diagnostics
Background:
- Transient elevations in serum alkaline phosphatase (ALP) can occur in infants.
- Understanding the etiology and clinical significance of such elevations is crucial for accurate diagnosis.
Observation:
- Two infants presented with striking, transient increases in serum alkaline phosphatase.
- Isoenzyme analysis revealed elevated activity in both bone and liver fractions.
Findings:
- The observed increase in alkaline phosphatase activity persisted for approximately 4-6 weeks.
- The exact cause remains unknown, though an infectious etiology is considered.
- This condition may be asymptomatic and potentially frequent in the pediatric population.
Implications:
- Awareness of this transient hyperphosphatasemia is important for clinicians.
- Knowledge of this condition can help avoid unnecessary and potentially invasive diagnostic procedures in infants.
- Further research into the etiology and prevalence of this phenomenon is warranted.
Abstract:
Striking transient increases in serum alkaline phosphatase in 2 infants are reported. Isoenzymes were studied in 2 infants and increased activity was found in bone as well as in liver fractions. Repeated serum determinations demonstrated a duration of about 4-6 weeks. The etiology is unknown but an infectious cause is discussed. The condition may be rather frequent but gives no obvious symptoms. It is important to know this condition to avoid unnecessary diagnostic procedures.