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Related Experiment Videos

[Transient hyperphosphatasemia in infants].

R Colli1, G Frigerio, G A Bianchi

  • 1Divisione di Pediatria, USSL n. 61, Carate Brianza, Milano.

Minerva Pediatrica
|November 1, 1990
PubMed
Summary
This summary is machine-generated.

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Transient elevations in serum alkaline phosphatase were observed in two infants. This bone and liver enzyme increase, lasting 4-6 weeks, may be linked to infection and warrants awareness to prevent unnecessary tests.

Area of Science:

  • Pediatric Medicine
  • Biochemistry
  • Clinical Diagnostics

Background:

  • Transient elevations in serum alkaline phosphatase (ALP) can occur in infants.
  • Understanding the etiology and clinical significance of such elevations is crucial for accurate diagnosis.

Observation:

  • Two infants presented with striking, transient increases in serum alkaline phosphatase.
  • Isoenzyme analysis revealed elevated activity in both bone and liver fractions.

Findings:

  • The observed increase in alkaline phosphatase activity persisted for approximately 4-6 weeks.
  • The exact cause remains unknown, though an infectious etiology is considered.
  • This condition may be asymptomatic and potentially frequent in the pediatric population.

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Implications:

  • Awareness of this transient hyperphosphatasemia is important for clinicians.
  • Knowledge of this condition can help avoid unnecessary and potentially invasive diagnostic procedures in infants.
  • Further research into the etiology and prevalence of this phenomenon is warranted.