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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Radiological Investigation II: MRI and Ventilation Perfusion Scan

Description
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MRI
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Related Experiment Video

Updated: Jun 9, 2026

Hyperpolarized Xenon for NMR and MRI Applications
16:20

Hyperpolarized Xenon for NMR and MRI Applications

Published on: September 6, 2012

MRI thermometry based on encapsulated hyperpolarized xenon.

Franz Schilling1, Leif Schröder, Krishnan K Palaniappan

  • 1Lawrence Berkeley National Laboratory, Materials Sciences Division, Berkeley, CA 94720, USA. fschilling@tum.de

Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry
|September 8, 2010
PubMed
Summary

We developed a novel MRI thermometry technique using hyperpolarized xenon. This method offers improved accuracy over water-based methods for temperature mapping in biomedical applications.

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Area of Science:

  • Nuclear Magnetic Resonance (NMR) Spectroscopy
  • Medical Imaging
  • Chemical Physics

Background:

  • Magnetic Resonance Imaging (MRI) thermometry is crucial for monitoring temperature changes in biological tissues.
  • Current MRI thermometry methods, often relying on water proton resonance frequency, have limitations in accuracy and sensitivity.
  • Hyperpolarized gases offer unique properties for advanced NMR applications.

Purpose of the Study:

  • To demonstrate a new MRI thermometry approach utilizing encapsulated hyperpolarized xenon.
  • To evaluate the temperature-dependent chemical shift of hyperpolarized xenon in a cryptophane-A cage.
  • To compare the sensitivity and accuracy of this novel method with existing MRI thermometry techniques.

Main Methods:

  • Encapsulation of hyperpolarized xenon within cryptophane-A cages to create a temperature-sensitive NMR sensor.
  • Utilizing spectroscopic imaging techniques for direct NMR detection of the xenon chemical shift.
  • Employing Hyperpolarized Chemical Exchange Saturation Transfer (Hyper-CEST) for indirect detection at nanomolar concentrations.

Main Results:

  • The xenon-in-cage chemical shift exhibits a linear temperature dependence with a slope of 0.29 ppm/°C, significantly higher than water.
  • Temperature maps of phantom samples demonstrated discrimination of 0.1 °C differences at 150 μM sensor concentration via direct detection.
  • Indirect detection using Hyper-CEST enabled thermometry at nanomolar agent concentrations.

Conclusions:

  • Hyperpolarized xenon-based MRI thermometry provides enhanced accuracy and sensitivity compared to current methods.
  • This technique holds promise for precise temperature monitoring in biomedical research and clinical applications.
  • Functionalization of xenon sensors for specific molecular targets could enable targeted biosensing applications.