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Updated: Jun 9, 2026

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
Published on: January 31, 2022
Balantidium coli-induced pulmonary haemorrhage with iron deficiency
Background:
Balantidium coli, a ciliated protozoan parasite that infects primates and pigs, and is the largest protozoan to infect humans, is a well-known cause of diarrhoea and dysentery in humans. Extra-intestinal disease is uncommon, however.
Objective:
We describe a case of lung involvement, with severe pulmonary haemorrhage resulting in iron deficiency anaemia and respiratory failure, of a 20-year-old, immune-competent man.
Results:
Diagnosis was made by bronchial biopsy and lavage, which showed numerous trophozoites compatible with B. coli with a background of acute inflammatory cells. The origin of infection was not clear, but inhalation of pig manure was postulated as there was no history of intestinal disease. The patient was treated with oxytetracyline and metronidazole, kept in an ICU, improved within 48 hours, and was discharged within 4 days.
Conclusion:
B. coli infection should be considered as part of the differential diagnosis of pulmonary haemorrhage.
Insights
Balantidium coli, a parasitic protozoan, can cause rare lung infections leading to severe pulmonary hemorrhage. Early diagnosis and treatment with antibiotics are crucial for patient recovery.
Area of Science:
- Parasitology
- Pulmonology
- Infectious Diseases
Background:
- Balantidium coli is a protozoan parasite typically causing intestinal disease (diarrhea, dysentery) in humans.
- Extra-intestinal infections by Balantidium coli are uncommon.
Observation:
- A case of a 20-year-old immunocompetent male with severe pulmonary hemorrhage, iron deficiency anemia, and respiratory failure is presented.
- Diagnosis was confirmed via bronchial biopsy and lavage, revealing Balantidium coli trophozoites.
Findings:
- Inhalation of contaminated material (e.g., pig manure) was postulated as the infection route, despite no history of intestinal disease.
- The patient received oxytetracycline and metronidazole, intensive care, and showed rapid improvement within 48 hours.
Implications:
- Balantidium coli infection should be considered in the differential diagnosis of pulmonary hemorrhage.
- This case highlights the potential for unusual extra-intestinal manifestations of Balantidium coli infection.
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