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The UCT Department of Medicine at 90 years: continuity and change
South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
|September 9, 2010
Abstract
No abstract available in PubMed .
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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