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Updated: Aug 31, 2026

10:26
Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
[Modelling and treatment of experimental inflammation of the periodontium]
Patologicheskaia Fiziologiia I Eksperimental'Naia Terapiia
|November 1, 1990
Abstract:
The study was conducted on 27 Californian breed rabbits and 55 albino mongrel rats. Periodontitis was reproduced in the animals by the ligature method, with the development of clinico-radiological signs characteristic of the disease and similar to those in humans. Correcting therapy of experimental periodontitis by means of lysozymy ultraphonophoresis contributed to the arrest of inflammation in the periodontal tissues, restoration of the calcium content and alkaline phosphatase activity in the blood serum of the animals, and increase of local and general unspecific resistance of the organism.

