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Detection of cardiovascular system involvement in Behçet's disease using fluorodeoxyglucose positron emission
Sung Bin Cho1, Mijin Yun, Jae-Hoon Lee
1Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Insights
18F-fluorodeoxyglucose positron emission tomography (FDG-PET) can help detect cardiovascular issues in Behçet's disease (BD). This imaging technique shows potential for evaluating vascular complications in BD patients.
Area of Science:
- Vascular Medicine
- Nuclear Medicine
- Rheumatology
Background:
- Behçet's disease (BD) is a multisystem vasculitis with potential cardiovascular involvement.
- Limited data exists on the utility of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in assessing cardiovascular manifestations of BD.
Purpose of the Study:
- To evaluate the clinical efficacy of FDG-PET in patients with Behçet's disease.
- To investigate the role of FDG-PET in identifying cardiovascular presentations associated with BD.
Main Methods:
- Retrospective review of medical records and FDG-PET scans from eight BD patients.
- Analysis of cardiovascular findings and FDG uptake in relation to clinical data.
Main Results:
- FDG uptake was observed in various vascular abnormalities including pseudoaneurysms, aortitis, arteritis, and aneurysms.
- Significant association found between quantitative FDG uptake intensity and erythrocyte sedimentation rate (ESR).
Conclusions:
- FDG-PET imaging may be a valuable tool for the workup of cardiovascular presentations in Behçet's disease.
- FDG-PET can aid in the detection and characterization of vascular inflammation in BD.
Objectives:
Behçet's disease (BD) theoretically affects all sizes and types of vessels; however, there have been few reports describing the clinical efficacy of using (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) in patients with BD.
Methods:
Eight patients who were registered at the BD Specialty Clinic of Severance Hospital between 2004 and 2008 underwent FDG-PET scans to evaluate the cardiovascular presentations associated with BD. Medical records and FDG-PET images of the patients were retrospectively reviewed to determine the clinical significance of the cardiovascular findings.
Results:
The median quantitative FDG uptake index was 1.46 (range, 0.58-2.61). FDG uptake was detected in multiple pseudoaneurysms, aortitis and arteritis associated with aortic regurgitation, and aneurysmatic dilation of the sinus of Valsalva, atherosclerotic change of the proximal ascending aorta associated with aortic regurgitation, and multiple pulmonary artery aneurysms. The quantitative FDG uptake intensity was significantly associated with the ESR level.
Conclusions:
FDG-PET scans may have clinical value as a workup study for patients with BD who have cardiovascular presentations.
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