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Updated: Jun 9, 2026

Perspectives on Neuroscience
Published on: July 31, 2007
NF-kappaB: much learned, much to learn
1Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, 609 Charles E. Young Drive East, Los Angeles, CA 90095, USA.
Abstract:
Although NF-kappaB (nuclear factor kappaB) was discovered less than 25 years ago, it is one of the most well-studied transcription factors. It plays critical roles in various immune and cellular processes, and its dysregulation is a major driver of cancer and inflammatory pathology. A new book published by Cold Spring Harbor Laboratory Press, NF-kappaB: A Network Hub Controlling Immunity, Inflammation, and Cancer, provides a series of excellent reviews on the architecture, regulation, and pathophysiological roles of NF-kappaB signaling by some of the leading investigators in the field.
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