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Treatment of infections caused by antimicrobial-resistant gram-positive bacteria

Karen K Kinney1

  • 1Infectious Diseases Section, Department of Medicine, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma 73190, USA. karenkinney@ouhsc.edu

The American Journal of the Medical Sciences
|September 9, 2010
PubMed

Insights

Methicillin-resistant Staphylococcus aureus (MRSA) and resistant Enterococcus infections pose treatment challenges. Newer antibiotics show promise, but emerging resistance necessitates ongoing research for effective therapies.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Increasing prevalence of methicillin-resistant Staphylococcus aureus (MRSA) infections.
  • Challenges in treating MRSA due to vancomycin treatment failures and emerging resistance.
  • Growing antimicrobial resistance in Enterococcus species.

Purpose of the Study:

  • To review current treatment options for resistant Gram-positive bacterial infections.
  • To discuss the role of newer antimicrobial agents against resistant pathogens.
  • To highlight the emergence of resistance to newer drugs and the need for novel therapies.

Main Methods:

  • Literature review of antimicrobial resistance trends.
  • Analysis of clinical data on treatment outcomes for resistant infections.
  • Examination of emerging antimicrobial agents and their resistance profiles.

Main Results:

  • Vancomycin treatment failures are increasing for MRSA infections.
  • Newer agents like linezolid, daptomycin, tigecycline, and telavancin are available but face emerging resistance.
  • Development of new antibiotics, including cephalosporins and carbapenems with MRSA activity, is ongoing.

Conclusions:

  • Effective treatment of resistant Gram-positive infections is a significant clinical challenge.
  • Continuous monitoring of antimicrobial resistance and development of new drugs are crucial.
  • Novel therapeutic strategies are needed to combat evolving resistance patterns.

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