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Updated: Jun 9, 2026

Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth
Published on: January 7, 2022
Macrolides of the bafilomycin family produced by Streptomyces sp. CS
Jian Li1, Chunhua Lu, Yuemao Shen
1Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Fujian, PR China.
Abstract:
Five new 16-membered macrolides (1-5), belonging to the bafilomycin subfamily, were isolated from the fermentation broth of Streptomyces sp. CS, a commensal microbe of Maytenus hookeri. Their structures including relative configurations were elucidated based on NMR data and analysis of single crystal X-ray diffraction data. The cytotoxicities of compounds 1-5 on the MDA-MB-435 cell line were analyzed by the MTT method and the IC(50) values were found to be 4.2, 4.5, 5.5, 3.8 and 11.4 μM, respectively.
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